Back and forth between cell fate specification and movement during vertebrate gastrulation Journal Article


Author(s): Heisenberg, Carl-Philipp; Solnica-Krezel, Lilianna
Article Title: Back and forth between cell fate specification and movement during vertebrate gastrulation
Affiliation
Abstract: Animal body plan arises during gastrulation and organogenesis by the coordination of inductive events and cell movements. Several signaling pathways, such as BMP, FGF, Hedgehog, Nodal, and Wnt have well-recognized instructive roles in cell fate specification during vertebrate embryogenesis. Growing evidence indicates that BMP, Nodal, and FGF signaling also regulate cell movements, and that they do so through mechanisms distinct from those that specify cell fates. Moreover, pathways controlling cell movements can also indirectly influence cell fate specification by regulating dimensions and relative positions of interacting tissues. The current challenge is to delineate the molecular mechanisms via which the major signaling pathways regulate cell fate specification and movements, and how these two processes are coordinated to ensure normal development.
Keywords: Models, Biological; Cell Movement; Cell Differentiation; Body Patterning; Bone Morphogenetic Proteins; Fibroblast Growth Factors; Gastrula; Nodal Protein; Receptors, G-Protein-Coupled; Wnt Proteins
Journal Title: Current Opinion in Genetics & Development
Volume: 18
Issue 4
ISSN: 0959-437X
Publisher: Elsevier  
Date Published: 2008-01-01
Start Page: 311
End Page: 316
DOI: 10.1016/j.gde.2008.07.011
Open access: no