The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation Journal Article


Author(s): Kilian, Beate; Mansukoski, Hannu; Barbosa, Filipa Carreira; Ulrich, Florian; Tada, Masazumi; Heisenberg, Carl-Philipp
Article Title: The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation
Affiliation
Abstract: Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Keywords: Gastrulation; Zebrafish; Convergent extension; Wnt signalling
Journal Title: Mechanisms of Development
Volume: 120
Issue 4
ISSN: 0925-4773
Publisher: Elsevier  
Date Published: 2003-04-01
Start Page: 467
End Page: 476
DOI: 10.1016/S0925-4773(03)00004-2
Open access: no