Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces Journal Article


Author(s): Oteíza, Pablo; Köppen, Mathias; Krieg, Michael; Preibisch, Steffen; Haertel, Steffen; Müller, Daniel J; Heisenberg, Carl-Philipp; Concha, Miguel
Article Title: Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces
Affiliation
Abstract: Organ formation requires the precise assembly of progenitor cells into a functional unit. Mechanical forces are likely to play a critical role in this process, but it is unclear how these are molecularly controlled during development. Here, we show that Wnt11/ Pk1a-mediated planar cell polarity (PCP) signalling coordinates formation of the zebrafish laterality organ (Kupffer’s vesicle, KV) by regulating adhesion forces between organ progenitor cells (the dorsal forerunner cells, DFCs).
Journal Title: Mechanisms of Development
Volume: 126
Issue Supplement 1
ISSN: 0925-4773
Publisher: Elsevier  
Date Published: 2009-08-05
Start Page: S80
End Page: S80
DOI: 10.1016/j.mod.2009.06.098
Open access: no