Linking organ formation to left-right patterning in the embryonic zebrafish Journal Article


Author(s): Oteíza, Pablo; Lemus, Carmen; Köppen, Mathias; Palma, Karina; Krieg, Michael; Melo, Cristina; Farias, Cecilia; Pulgar, Eduardo; Preibisch, Steffen; Hartel, Steffen; Heisenberg, Carl-Philipp; Concha, Miguel
Article Title: Linking organ formation to left-right patterning in the embryonic zebrafish
Affiliation
Abstract: While the function of patterning in organogenesis is being extensively studied, considerably less is known of reverse effects that organ formation imposes on patterning. In zebrafish, the Kupffer’s vesicle (KV) and parapineal (PP) are embryonic struc- tures that share mechanisms of organogenesis and whose func- tion is essential for normal patterning along the left–right axis. Early morphogenesis of KV and PP organs involve the compaction of progenitor cells into a tight cluster within which three-dimen- sional cellular rosettes are formed. Organisation into rosettes pre- cedes the detachment of progenitor cells from neighbouring tissue and thus represents a key step towards organ formation. Such morphogenetic event is essential for organ function and its disruption has profound effects on left–right patterning.
Journal Title: Mechanisms of Development
Volume: 126
Issue Supplement 1
ISSN: 0925-4773
Publisher: Elsevier  
Date Published: 2009-08-05
Start Page: S11
End Page: S11
Sponsor: Grant sponsors: HHMI, CONICYT (PBCT ACT47, PBCT Red6), ICM P04-048-F, EU FP6-2004-NEST-PATH EDCBNL, DAAD.
DOI: 10.1016/j.mod.2009.06.970
Open access: no