Biology and physics of cell shape changes in development Journal Article


Author(s): Paluch, Ewa; Heisenberg, Carl-Philipp
Article Title: Biology and physics of cell shape changes in development
Affiliation
Abstract: Together with cell growth, division and death, changes in cell shape are of central importance for tissue morphogenesis during development. Cell shape is the product of a cell's material and active properties balanced by external forces. Control of cell shape, therefore, relies on both tight regulation of intracellular mechanics and the cell's physical interaction with its environment. In this review, we first discuss the biological and physical mechanisms of cell shape control. We next examine a number of develop mental processes in which cell shape change - either individually or in a coordinated manner - drives embryonic morphogenesis and discuss how cell shape is controlled in these processes. Finally, we emphasize that cell shape control during tissue morphogenesis can only be fully understood by using a combination of cellular, molecular, developmental and biophysical approaches.
Keywords: Cell Movement; Biomechanics; Cell Adhesion; Cell Shape; Drosophila; Zebrafish; Body Patterning; Cell Growth Processes; Embryo, Nonmammalian; Embryonic Development
Journal Title: Current Biology
Volume: 19
Issue 17
ISSN: 0960-9822
Publisher: Cell Press  
Date Published: 2009-09-15
Start Page: R790
End Page: R799
DOI: 10.1016/j.cub.2009.07.029
Open access: no
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