Zebrafish gastrulation: Cell movements, signals, and mechanisms Journal Article


Author(s): Rohde, Laurel A; Heisenberg, Carl-Philipp
Article Title: Zebrafish gastrulation: Cell movements, signals, and mechanisms
Affiliation
Abstract: Gastrulation is a morphogenetic process that results in the formation of the embryonic germ layers. Here we detail the major cell movements that occur during zebrafish gastrulation: epiboly, internalization, and convergent extension. Although gastrulation is known to be regulated by signaling pathways such as the Wnt/planar cell polarity pathway, many questions remain about the underlying molecular and cellular mechanisms. Key factors that may play a role in gastrulation cell movements are cell adhesion and cytoskeletal rearrangement. In addition, some of the driving force for gastrulation may derive from tissue interactions such as those described between the enveloping layer and the yolk syncytial layer. Future exploration of gastrulation mechanisms relies on the development of sensitive and quantitative techniques to characterize embryonic germ-layer properties.
Keywords: Gastrulation; Zebrafish; Wnt; Enveloping layer (EVL); Yolk syncytial layer (YSL); Differential adhesion
Journal Title: International Review of Cytology - A Survey of Cell Biology
Volume: 261
ISSN: 0074-7696
Publisher: Academic Press  
Date Published: 2007-06-06
Start Page: 159
End Page: 192
DOI: 10.1016/S0074-7696(07)61004-3
Open access: no