Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons Journal Article


Author(s): Hu, Hua; Martina, Marco; Jonas, Peter
Article Title: Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons
Affiliation
Abstract: Fast-spiking, parvalbumin-expressing basket cells (BCs) are important for feedforward and feedback inhibition. During network activity, BCs respond with short latency and high temporal precision. It is thought that the specific properties of input synapses are responsible for rapid recruitment. However, a potential contribution of active dendritic conductances has not been addressed. We combined confocal imaging and patch-clamp techniques to obtain simultaneous somatodendritic recordings from BCs. Action potentials were initiated in the BC axon and backpropagated into the dendrites with reduced amplitude and little activity dependence. These properties were explained by a high K+ to Na+ conductance ratio in BC dendrites. Computational analysis indicated that dendritic K+ channels convey unique integration properties to BCs, leading to the rapid and temporally precise activation by excitatory inputs.
Keywords: Animals; Rats; Synaptic Transmission; Patch-Clamp Techniques; Rats, Wistar; Action Potentials; Axons/physiology; Excitatory Postsynaptic Potentials; Hippocampus/cytology/*physiology; Ion Channel Gating; Microscopy, Confocal; Neural Inhibition; Parvalbumins/metabolism; Potassium/metabolism; Potassium Channels, Voltage-Gated/metabolism; Sodium/metabolism; Sodium Channels/metabolism; Synapses/physiology; Interneurons/physiology; Dendrites/physiology; Dentate Gyrus/cytology/physiology
Journal Title: Science
Volume: 327
Issue 5961
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Publication Place: United States
Date Published: 2010-01-01
Start Page: 52
End Page: 8
DOI: 10.1126/science.1177876
Open access: no