Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks (Review) Journal Article


Author(s): Bartos, Marlene; Vida, Imre; Jonas, Peter
Article Title: Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks (Review)
Affiliation
Abstract: Gamma frequency oscillations are thought to provide a temporal structure for information processing in the brain. They contribute to cognitive functions, such as memory formation and sensory processing, and are disturbed in some psychiatric disorders. Fast-spiking, parvalbumin-expressing, soma-inhibiting interneurons have a key role in the generation of these oscillations. Experimental analysis in the hippocampus and the neocortex reveals that synapses among these interneurons are highly specialized. Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.
Keywords: Animals; Humans; Neural Inhibition; Synapses/physiology; Brain/cytology; Neural Networks (Computer); Periodicity; Interneurons/physiology; Nerve Net/physiology
Journal Title: Nature Reviews Neuroscience
Volume: 8
Issue 1
ISSN: 1471-003X
Publisher: Nature Publishing Group  
Publication Place: England
Date Published: 2007-01-21
Start Page: 45
End Page: 56
DOI: 10.1038/nrn2044
Open access: no