TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus Journal Article


Author(s): Bischofberger, Josef; Jonas, Peter
Article Title: TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus
Affiliation
Abstract: Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner.
Keywords: Animals; Pyramidal Cells/physiology; Receptors, AMPA/physiology; Synaptic Transmission/physiology; Synapses/physiology; Receptors, N-Methyl-D-Aspartate/physiology; Interneurons/physiology; ; NMDA; Mossy Fibers, Hippocampal/physiology; Hippocampus; mossy fiber; CA3; synapse; interneuron; AMPA
Journal Title: Trends in Neurosciences
Volume: 25
Issue 12
ISSN: 0166-2236
Publisher: Elsevier  
Publication Place: England
Date Published: 2002-12-01
Start Page: 600
End Page: 603
DOI: 10.1016/S0166-2236(02)02259-2
Open access: no