Cell sorting in development Book Section

Author(s): Krens, Gabriel; Heisenberg, Carl-Philipp
Editor(s): Labouesse, Michel
Article/Chapter Title: Cell sorting in development
Title Series: Current Topics in Developmental Biology
Affiliation IST Austria
Abstract: During the development of multicellular organisms, cell fate specification is followed by the sorting of different cell types into distinct domains from where the different tissues and organs are formed. Cell sorting involves both the segregation of a mixed population of cells with different fates and properties into distinct domains, and the active maintenance of their segregated state. Because of its biological importance and apparent resemblance to fluid segregation in physics, cell sorting was extensively studied by both biologists and physicists over the last decades. Different theories were developed that try to explain cell sorting on the basis of the physical properties of the constituent cells. However, only recently the molecular and cellular mechanisms that control the physical properties driving cell sorting, have begun to be unraveled. In this review, we will provide an overview of different cell-sorting processes in development and discuss how these processes can be explained by the different sorting theories, and how these theories in turn can be connected to the molecular and cellular mechanisms driving these processes.
Keywords: Cell sorting; Tissue Surface Tension; Parallel plate compression apparatus; differential adhesion hypothesis
Book Title: Forces and Tension in Development
Volume: 95
ISBN: 978-0-12-385065-2
Publisher: Elsevier  
Publication Place: San Diego, CA, USA
Date Published: 2011-04-16
Start Page: 189
End Page: 213
DOI: 10.1016/B978-0-12-385065-2.00006-2
Notes: Chapter 6
Open access: no