Modeling network dynamics: the lac operon, a case study Journal Article

Author(s): Vilar, Jose M; Guet, Cǎlin C; Leibler, Stanislas
Article Title: Modeling network dynamics: the lac operon, a case study
Abstract: We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.
Keywords: Animals; Models, Biological; Humans; Lactose; Computational Biology/methods; Escherichia coli/genetics; Escherichia coli/metabolism; Computational Biology/trends; Lac Operon/genetics; Lactose/genetics; Lactose/metabolism; Nonlinear Dynamics;
Journal Title: Journal of Cell Biology
Volume: 161
Issue 3
ISSN: 0021-9525
Publisher: Rockefeller University Press  
Date Published: 2003-01-12
Start Page: 471
End Page: 476
DOI: 10.1083/jcb.200301125
Open access: yes (repository)