Diffusion, dimensionality, and noise in transcriptional regulation Journal Article


Author(s): Tkačik, Gašper; Bialek, William S
Article Title: Diffusion, dimensionality, and noise in transcriptional regulation
Affiliation
Abstract: The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to specific sites on DNA and regulating transcription, the ability of the proteins to diffuse in one dimension by sliding along the length of the DNA, in addition to their diffusion in bulk solution, would seem to generate a larger target for DNA binding, consequently reducing the noise in the occupancy of the regulatory site. Here we show that this effect is largely canceled by the enhanced temporal correlations in one-dimensional diffusion. With realistic parameters, sliding along DNA has surprisingly little effect on the physical limits to the precision of transcriptional regulation.
Keywords: Computer Simulation; Gene Expression Regulation; Models: Chemical; Models: Genetic; Models: Statistical; Transcription Factors; Transcriptional Activation; DNA
Journal Title: Physical Review E Statistical Nonlinear and Soft Matter Physics
Volume: 79
Issue 5
ISSN: 1539-3755
Publisher: American Institute of Physics  
Date Published: 2009-05-04
Start Page: 051901
DOI: 10.1103/PhysRevE.79.051901
Open access: no
IST Austria Authors
  1. Gasper Tkacik
    67 Tkacik