Genome size: Does bigger mean worse? Review Article

Author(s): Charlesworth, Brian; Barton, Nicholas H
Title: Genome size: Does bigger mean worse?
Abstract: Genome sizes vary enormously. This variation in DNA content correlates with effective population size, suggesting that deleterious additions to the genome can accumulate in small populations. On this view, the increased complexity of biological functions associated with large genomes partly reflects evolutionary degeneration.
Publication Title: Current Biology
Volume: 14
Issue 6
ISBN: 0960-9822
Publisher: Cell Press  
Date Published: 2004-03-01
Start Page: R233
End Page: R235
DOI: 10.1016/j.cub.2004.02.054
Open access: no