Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events Journal Article


Author(s): Csicsvári, József; Hirase, Hajima; Mamiya, Akira; Buzsáki, György
Article Title: Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events
Affiliation
Abstract: Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons.
Keywords: Animals; Rats; Male; Rats, Sprague-Dawley; Action Potentials; Signal Processing, Computer-Assisted; Hippocampus; Interneurons; Pyramidal Cells; Biological Clocks; Electrodes, Implanted; Reproducibility of Results; Wakefulness
Journal Title: Neuron
Volume: 28
Issue 2
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2000-11-01
Start Page: 585
End Page: 594
DOI: 10.1016/S0896-6273(00)00135-5
Open access: no