Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity Journal Article


Author(s): Fuentealba, Pablo; Begum, Rahima; Capogna, Marco; Jinno, Shozo; Marton, Laszlo F; Csicsvári, József; Thomson, Alex; Somogyi, Péter; Klausberger, Thomas
Article Title: Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity
Affiliation
Abstract: In the cerebral cortex, GABAergic interneurons are often regarded as fast-spiking cells. We have identified a type of slow-spiking interneuron that offers distinct contributions to network activity. “Ivy” cells, named after their dense and fine axons innervating mostly basal and oblique pyramidal cell dendrites, are more numerous than the parvalbumin-expressing basket, bistratified, or axo-axonic cells. Ivy cells express nitric oxide synthase, neuropeptide Y, and high levels of GABA(A) receptor alpha 1 subunit; they discharge at a low frequency with wide spikes in vivo, yet are distinctively phase-locked to behaviorally relevant network rhythms including theta, gamma, and ripple oscillations. Paired recordings in vitro showed that Ivy cells receive depressing EPSPs from pyramidal cells, which in turn receive slowly rising and decaying inhibitory input from Ivy cells. In contrast to fast-spiking interneurons operating with millisecond precision, the highly abundant Ivy cells express presynaptically acting neuromodulators and regulate the excitability of pyramidal cell dendrites through slowly rising and decaying GABAergic inputs.
Keywords: Animals; Rats; Male; Rats, Sprague-Dawley; Animals, Newborn; Electric Stimulation; Synaptic Transmission; Patch-Clamp Techniques; Action Potentials; Nerve Net; Neurons; Behavior, Animal; Hippocampus; Cerebral Cortex; Biotin; gamma-Aminobutyric Acid; Microscopy, Immunoelectron; Nerve Tissue Proteins; Nitric Oxide; Parvalbumins; Receptors, GABA-A
Journal Title: Neuron
Volume: 57
Issue 6
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2008-03-27
Start Page: 917
End Page: 929
DOI: 10.1016/j.neuron.2008.01.034
Open access: no