Mechanisms of gamma oscillations in the hippocampus of the behaving rat Journal Article


Author(s): Csicsvári, József; Jamieson, Brian G; Wise, Kensall D; Buzsáki, György
Article Title: Mechanisms of gamma oscillations in the hippocampus of the behaving rat
Alternate Title: NEURON
Affiliation
Abstract: Gamma frequency oscillations (30-100 Hz) have been suggested to underlie various cognitive and motor functions. Here, we examine the generation of gamma oscillation currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two gamma generators were identified, one in the dentate gyrus and another in the CA3-CA1 regions. The coupling strength between the two oscillators varied during both theta and nontheta states. Both pyramidal cells and interneurons were phase-locked to gamma waves. Anatomical connectivity, rather than physical distance, determined the coupling strength of the oscillating neurons. CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons.
Journal Title: Neuron
Volume: 37
Issue 2
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2003-01-01
Start Page: 311
End Page: 322
DOI: 10.1016/S0896-6273(02)01169-8
Open access: no