Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior Journal Article


Author(s): O'Neill, Joseph; Senior, Timothy; Csicsvári, József
Article Title: Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory behavior
Affiliation
Abstract: We observed sharp wave/ripples (SWR) during exploration within brief (< 2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a “supralinear” summation of eSWR and place-selective inputs. Pairs of cells with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs.
Keywords: Animals; Rats; Male; Electrophysiology; Action Potentials; Pyramidal Cells; Wakefulness; Theta Rhythm; Exploratory Behavior; Rats, Inbred Strains; Sleep Stages; Space Perception
Journal Title: Neuron
Volume: 49
Issue 1
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2006-01-05
Start Page: 143
End Page: 155
DOI: 10.1016/j.neuron.2005.10.037
Open access: no