Distal initiation and active propagation of action potentials in interneuron dendrites Journal Article


Author(s): Martina, Marco; Vida, Imre; Jonas, Peter
Article Title: Distal initiation and active propagation of action potentials in interneuron dendrites
Affiliation
Abstract: Fast and reliable activation of inhibitory interneurons is critical for the stability of cortical neuronal networks. Active conductances in dendrites may facilitate interneuron activation, but direct experimental evidence was unavailable. Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous recordings from dendrites and somata suggested that action potential initiation occurs preferentially in the axon with long threshold stimuli, but can be shifted to somatodendritic sites when brief stimuli are applied. After initiation, action potentials propagate over the somatodendritic domain with constant amplitude, high velocity, and reliability, even during high-frequency trains.
Keywords: Animals; Rats; Potassium; Sodium; Patch-Clamp Techniques; Rats, Wistar; Action Potentials; Excitatory Postsynaptic Potentials; Ion Channel Gating; Potassium Channels; Sodium Channels; Axons; Hippocampus; Interneurons; Synapses; Dendrites; Tetrodotoxin; Somatostatin
Journal Title: Science
Volume: 287
Issue 5451
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2000-01-14
Start Page: 295
End Page: 300
DOI: 10.1126/science.287.5451.295
Open access: no