Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse Journal Article


Author(s): Geiger, Jörg R; Lubke, Joachim H; Roth, Arnd; Frotscher, Michael; Jonas, Peter
Article Title: Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse
Affiliation
Abstract: Glutamatergic transmission at a principal neuroninterneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration ≃ 4 ms; 34°C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.
Keywords: Animals; Time Factors; Rats; Signal Transduction; Synaptic Transmission; Patch-Clamp Techniques; Rats, Wistar; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Evoked Potentials; Hippocampus; Interneurons; Brain Mapping
Journal Title: Neuron
Volume: 18
Issue 6
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 1997-06-01
Start Page: 1009
End Page: 1023
DOI: 10.1016/S0896-6273(00)80339-6
Open access: no