Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS Journal Article


Author(s): Jonas, Peter; Spruston, Nelson
Article Title: Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS
Affiliation
Abstract: Excitatory postsynaptic currents in neurones of the central nervous system have a dual-component time course that results from the co-activation of AMPA/kainate-type and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular biology have provided a better understanding of the factors that determine the kinectics of excitatory postsynaptic currents. Recent studies suggest that the time course of neurotransmitter concentration in the synaptic cleft, the gating properties of the native channels, and the glutamate receptor subunit composition all appear to be important factors.
Keywords: Animals; Humans; Electrophysiology; Kinetics; Receptors, AMPA/physiology; Synapses/physiology; Ion Channels/metabolism; Ion Channels; Receptors, AMPA; Receptors, Glutamate; Glutamic Acid; Receptors, Kainic Acid/physiology; Receptors, Kainic Acid; Central Nervous System/physiology; Glutamic Acid/physiology; Receptors, Glutamate/metabolism
Journal Title: Current Opinion in Neurobiology
Volume: 4
Issue 3
ISSN: 0959-4388
Publisher: Elsevier  
Date Published: 1994-06-01
Start Page: 366
End Page: 372
DOI: 10.1016/0959-4388(94)90098-1
Open access: no