The multiple faces of RIM Journal Article


Author(s): Pernía-Andrade, Alejandro; Jonas, Peter
Article Title: The multiple faces of RIM
Affiliation IST Austria
Abstract: Rab3 interacting molecules (RIMs) are highly enriched in the active zones of presynaptic terminals. It is generally thought that they operate as effectors of the small G protein Rab3. Three recent papers, by Han et al. (this issue of Neuron), Deng et al. (this issue of Neuron), and Kaeser et al. (a recent issue of Cell), shed new light on the functional role of RIM in presynaptic terminals. First, RIM tethers Ca2+ channels to active zones. Second, RIM contributes to priming of synaptic vesicles by interacting with another presynaptic protein, Munc13.
Journal Title: Neuron
Volume: 69
Issue 2
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2011-01-27
Start Page: 185
End Page: 187
DOI: 10.1016/j.neuron.2011.01.010
Open access: no