Enveloping cell layer differentiation at the surface of zebrafish germ layer tissue explants Journal Article


Author(s): Krens, Gabriel; Moellmert, Stephanie; Heisenberg, Carl-Philipp
Article Title: Enveloping cell layer differentiation at the surface of zebrafish germ layer tissue explants
Affiliation IST Austria
Abstract: Tissue surface tension (TST) is an important mechanical property influencing cell sorting and tissue envelopment. The study by Manning et al. (1) reported on a mathematical model describing TST on the basis of the balance between adhesive and tensile properties of the constituent cells. The model predicts that, in high-adhesion cell aggregates, surface cells will be stretched to maintain the same area of cell–cell contact as interior bulk cells, resulting in an elongated and flattened cell shape. The authors (1) observed flat and elongated cells at the surface of high-adhesion zebrafish germ-layer explants, which they argue are undifferentiated stretched germ-layer progenitor cells, and they use this observation as a validation of their model. We disagree with the view that the surface cells of germ-layer explants described in ref. 1 are undifferentiated stretched germ-layer progenitor cells and argue that they are instead differentiated simple squamous epithelial enveloping-layer (EVL) cells.
Journal Title: PNAS
Volume: 108
Issue 3
ISSN: 1091-6490
Publisher: National Academy of Sciences  
Date Published: 2011-01-18
Start Page: E9
End Page: E10
URL:
DOI: 10.1073/pnas.1010767108
Open access: yes (repository)