Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses Journal Article


Author(s): Eggermann, Emmanuel; Bucurenciu, Iancu; Goswami, Sarit P; Jonas, Peter
Article Title: Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses
Affiliation IST Austria
Abstract: The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission.
Journal Title: Nature Reviews Neuroscience
Volume: 13
Issue 1
ISSN: 1471-003X
Publisher: Nature Publishing Group  
Date Published: 2012-01-01
Start Page: 7
End Page: 21
Sponsor: Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.
URL:
DOI: 10.1038/nrn3125
Notes: We thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A. Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial support. We apologize that owing to space constraints, not all relevant papers could be cited.
Open access: yes (repository)