A developmental switch in the response of DRG neurons to ETS transcription factor signaling Journal Article


Author(s): Hippenmeyer, Simon; Vrieseling, Eline; Sigrist, Markus; Portmann, Thomas; Laengle, Celia; Ladle, David R; Arber, Silvia
Article Title: A developmental switch in the response of DRG neurons to ETS transcription factor signaling
Affiliation
Abstract: Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation.
Keywords: Gene Expression; Signal Transduction; nonhuman; protein expression; article; Genetics; controlled study; animal tissue; cell maturation; cell subpopulation; mouse; nerve cell; nerve cell differentiation; nerve fiber; sensory nerve cell; spinal cord motoneuron; spinal ganglion
Journal Title: PLoS Biology
Volume: 3
Issue 5
ISSN: 1545-7885
Publisher: Public Library of Science  
Date Published: 2005-05-01
Start Page: 0878
End Page: 0890
Copyright Statement: CC BY
DOI: 10.1371/journal.pbio.0030159
Open access: yes (OA journal)