Control of neuronal phenotype: What targets tell the cell bodies Review Article

Author(s): Hippenmeyer, Simon; Kramer, Ina; Arber, Silvia
Title: Control of neuronal phenotype: What targets tell the cell bodies
Abstract: Assembly of neuronal circuits is controlled by the sequential acquisition of neuronal subpopulation-specific identities at progressive developmental steps. Whereas neuronal features involved in initial phases of differentiation are already established at cell-cycle exit, recent findings, based mainly on work in the peripheral nervous system, suggest that the timely integration of signals encountered en route to targets and from the target region itself is essential to control late steps in connectivity. As neurons project towards their targets they require target-derived signals to establish mature axonal projections and acquire neuronal traits such as the expression of distinct combinations of neurotransmitters. Recent evidence presented in this review shows that this principle, of a signaling interplay between target-derived signals and neuronal cell bodies, is often mediated through transcriptional events and is evolutionarily conserved.
Keywords: Animals; Humans; Phenotype; Cell Differentiation; Signal Transduction; Synaptic Transmission; Drosophila; Neurons; Neural Pathways; Nervous system; Cell Communication; Ganglia, Sympathetic; Growth Cones; Nerve Growth Factors
Publication Title: Trends in Neurosciences
Volume: 27
Issue 8
ISBN: 0166-2236
Publisher: Elsevier  
Date Published: 2004-08-01
Start Page: 482
End Page: 488
DOI: 10.1016/j.tins.2004.05.012
Open access: no