Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA Journal Article


Author(s): Williams, Courtney; Chen, Wenyan; Lee, Chia-Hsueh; Yaeger, Daniel; Vyleta, Nicholas P; Smith, Stephen M
Article Title: Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA
Affiliation IST Austria
Abstract: Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+) regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.
Journal Title: Nature Neuroscience
Volume: 15
Issue 9
ISSN: 1546-1726
Publisher: Nature Publishing Group  
Date Published: 2012-07-29
Start Page: 1195
End Page: 1197
Sponsor: The work was supported by the US National Institutes of Health (DA027110 and GM097433) and OCTRI. C.W. and N.P.V. were supported by a grant from the National Heart, Lung, and Blood Institute (T32HL033808).
URL:
DOI: 10.1038/nn.3162
Notes: We thank M. Andresen and K. Khodakhah for helpful comments.
Open access: yes (repository)