Functional redundancy of PIN proteins is accompanied by auxin-dependent cross-regulation of PIN expression Journal Article


Author(s): Vieten, Anne; Vanneste, Steffen; Wiśniewska, Justyna; Benková, Eva; Benjamins, René; Beeckman, Tom; Luschnig, Christian; Friml, Jiří
Article Title: Functional redundancy of PIN proteins is accompanied by auxin-dependent cross-regulation of PIN expression
Affiliation
Abstract: Plant development displays an exceptional plasticity and adaptability that involves the dynamic, asymmetric distribution of the phytohormone auxin. Polar auxin flow, which requires polarly localized transport facilitators of the PIN family, largely contributes to the establishment and maintenance of the auxin gradients. Functionally overlapping action of PIN proteins mediates multiple developmental processes, including embryo formation, organ development and tropisms. Here we show that PIN proteins exhibit synergistic interactions, which involve cross-regulation of PIN gene expression in pin mutants or plants with inhibited auxin transport. Auxin itself positively feeds back on PIN gene expression in a tissue-specific manner through an AUX/IAA-dependent signalling pathway. This regulatory switch is indicative of a mechanism by which the loss of a specific PIN protein is compensated for by auxin-dependent ectopic: expression of its homologues. The compensatory properties of the PIN-dependent transport network might enable the stabilization of auxin gradients and potentially contribute to the robustness of plant adaptive development.
Keywords: Arabidopsis; Auxin transport; Functional redundancy; PINs
Journal Title: Development
Volume: 132
Issue 20
ISSN: 1477-9129
Publisher: Company of Biologists  
Date Published: 2005-10-01
Start Page: 4521
End Page: 4531
DOI: 10.1242/dev.02027
Open access: no