Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning Journal Article


Author(s): Dupret, David; O'Neill, Joseph; Csicsvári, József
Article Title: Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning
Affiliation IST Austria
Abstract: In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of pyramidal cells. We have found that CA1 interneuron circuits are also reconfigured during goal-oriented spatial learning through modification of inputs from pyramidal cells. As learning progressed, new pyramidal assemblies expressed in theta cycles alternated with previously established ones, and eventually overtook them. The firing patterns of interneurons developed a relationship to new, learning-related assemblies: some interneurons associated their activity with new pyramidal assemblies while some others dissociated from them. These firing associations were explained by changes in the weight of monosynaptic inputs received by interneurons from new pyramidal assemblies, as these predicted the associational changes. Spatial learning thus engages circuit modifications in the hippocampus that incorporate a redistribution of inhibitory activity that might assist in the segregation of competing pyramidal cell assembly patterns in space and time.
Journal Title: Neuron
Volume: 78
Issue 1
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2013-03-21
Start Page: 166
End Page: 180
Copyright Statement: CC BY
DOI: 10.1016/j.neuron.2013.01.033
Notes: We thank P. Somogyi, P. Jonas, K. Allen, and D. Dickerson for their construc- tive comments on a previous version of the manuscript and K. Lamsa for help- ful discussions; N. Campo-Urriza and L. Norman for their technical assistance. D.D. and J.C. were supported by a MRC Intramural Programme Grant (U138197111) and J.C. by a European Research Council Starter Grant (281511). D.D. currently holds a Research Fellowship in Neuroscience from Saint Edmund Hall College, University of Oxford. D.D. conducted the experi- ments. D.D. and J.O. carried out the data analysis. D.D. and J.C. wrote the manuscript. J.C. supervised the project. All authors discussed the results and commented on the manuscript.
Open access: yes (OA journal)