Right isomerism of the brain in inversus viscerum mutant mice Journal Article


Author(s): Kawakami, Ryosuke; Dobi, Alice; Shigemoto, Ryuichi; Ito, Isao
Article Title: Right isomerism of the brain in inversus viscerum mutant mice
Affiliation
Abstract: Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-O-aspartate receptor (NMDAR) subunit GluRε2 (NR2B) in hippocambal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry.
Keywords: n methyl dextro aspartic acid receptor 2B; n methyl dextro aspartic acid receptor; NR2B NMDA receptor
Journal Title: PLoS One
Volume: 3
Issue 4
ISSN: 1932-6203
Publisher: Public Library of Science  
Date Published: 2008-04-16
Copyright Statement: CC BY
DOI: 10.1371/journal.pone.0001945
Open access: yes (OA journal)