mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination Journal Article


Author(s): Ichise, Taeko; Kano, Masanobu; Hashimoto, Kouichi; Yanagihara, Dai; Nakao, Kazuki; Shigemoto, Ryuichi; Katsuki, Motoya; Aiba, Atsu
Article Title: mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination
Affiliation
Abstract: Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.
Keywords: metabotropic receptor
Journal Title: Science
Volume: 288
Issue 5472
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2000-06-09
Start Page: 1832
End Page: 1835
DOI: 10.1126/science.288.5472.1832
Open access: no