Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2 Review Article


Author(s): Yokoi, Mineto; Kobayashi, Kazuto; Manabe, Toshiya; Takahashi, Tomoyuki; Sakaguchi, Isako; Katsuura, Goro; Shigemoto, Ryuichi; Ohishi, Hitoshi; Nomura, Sakashi; Nakamura, Kenji; Nakao, Kazuki; Katsuki, Motoya; Nakanishi, Shigetada
Title: Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
Affiliation
Abstract: Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
Keywords: metabotropic receptor
Publication Title: Science
Volume: 273
Issue 5275
ISBN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 1996-08-02
Start Page: 645
End Page: 647
DOI: 10.1126/science.273.5275.645
Open access: no