Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone Journal Article


Author(s): Shigemoto, Ryuichi; Kulik, Ákos; Roberts, John D; Ohishi, Hitoshi; Nusser, Zoltán; Kaneko, Takeshi; Somogyi, Péter
Article Title: Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone
Affiliation
Abstract: The probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic auto receptors. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target
Keywords: Glutamate receptor; presynaptic receptor; metabotropic receptor
Journal Title: Nature
Volume: 381
Issue 6582
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 1996-06-06
Start Page: 523
End Page: 525
DOI: 10.1038/381523a0
Open access: no