A family of metabotropic glutamate receptors Journal Article


Author(s): Tanabe, Yasuto; Masu, Masayuki; Ishii, Takahiro; Shigemoto, Ryuichi; Nakanishi, Shigetada
Article Title: A family of metabotropic glutamate receptors
Affiliation
Abstract: Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.
Keywords: Glutamate receptor; Glutamic Acid; cyclic AMP; forskolin; guanine nucleotide binding protein; complementary dna; messenger rna
Journal Title: Neuron
Volume: 8
Issue 1
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 1992-01-01
Start Page: 169
End Page: 179
DOI: 10.1016/0896-6273(92)90118-W
Open access: no