Sequence and expression of a metabotropic glutamate receptor Journal Article


Author(s): Masu, Masayuki; Tanabe, Yasuto; Tsuchida, Kunihiro; Shigemoto, Ryuichi; Nakanishi, Shigetada
Article Title: Sequence and expression of a metabotropic glutamate receptor
Affiliation
Abstract: The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.
Keywords: Glutamate receptor
Journal Title: Nature
Volume: 349
Issue 6312
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 1991-02-28
Start Page: 760
End Page: 765
DOI: 10.1038/349760a0
Open access: no