Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling Journal Article


Author(s): Budreck, Elaine C; Kwon, Oh-Bin; Jung, Jung-Hoon; Baudouin, Stéphane J; Thommen, Albert; Kim, Hye-Sun; Fukazawa, Yugo; Harada, Harumi; Tabuchi, Katsuhiko; Shigemoto, Ryuichi; Scheiffele, Peter; Kim, Joung-Hun
Article Title: Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling
Affiliation
Abstract: Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cisinteractions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.
Keywords: synapse; Neurexin; Neurotranmitter receptor
Journal Title: PNAS
Volume: 110
Issue 2
ISSN: 1091-6490
Publisher: National Academy of Sciences  
Date Published: 2013-01-08
Start Page: 725
End Page: 730
DOI: 10.1073/pnas.1214718110
Open access: no