Molecular pathways controlling the sequential steps of cortical projection neuron migration Book Section


Editor(s): Hippenmeyer, Simon
Article/Chapter Title: Molecular pathways controlling the sequential steps of cortical projection neuron migration
Title Series: Advances in Experimental Medicine and Biology
Affiliation IST Austria
Abstract: Coordinated migration of newly-born neurons to their target territories is essential for correct neuronal circuit assembly in the developing brain. Although a cohort of signaling pathways has been implicated in the regulation of cortical projection neuron migration, the precise molecular mechanisms and how a balanced interplay of cell-autonomous and non-autonomous functions of candidate signaling molecules controls the discrete steps in the migration process, are just being revealed. In this chapter, I will focally review recent advances that improved our understanding of the cell-autonomous and possible cell-nonautonomous functions of the evolutionarily conserved LIS1/NDEL1-complex in regulating the sequential steps of cortical projection neuron migration. I will then elaborate on the emerging concept that the Reelin signaling pathway, acts exactly at precise stages in the course of cortical projection neuron migration. Lastly, I will discuss how finely tuned transcriptional programs and downstream effectors govern particular aspects in driving radial migration at discrete stages and how they regulate the precise positioning of cortical projection neurons in the developing cerebral cortex.
Keywords: Neuronal migration; Reelin; MADM; Cortex development; Lis1; Ndel1; Transcriptional regulation
Book Title: Cellular and Molecular Control of Neuronal Migration
Volume: 800
ISBN: 978-94-007-7686-9
Publisher: Springer  
Date Published: 2014-01-01
Start Page: 1
End Page: 24
DOI: 10.1007/978-94-007-7687-6_1
Open access: no