The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? Journal Article


Author(s): Vicoso, Beatriz; Charlesworth, Brian
Article Title: The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?
Affiliation
Abstract: In Drosophila, there is a consistent deficit of male-biased genes on the X chromosome. It has been suggested that male-biased genes may evolve from initially unbiased genes as a result of increased expression levels in males. If transcription rates are limited, a large increase in expression in the testis may be harder to achieve for single-copy X-linked genes than for autosomal genes, because they are already hypertranscribed due to dosage compensation. This hypothesis predicts that the larger the increase in expression required to make a male-biased gene, the lower the chance of this being achievable if it is located on the X chromosome. Consequently, highly expressed male-biased genes should be located on the X chromosome less often than lowly expressed male-biased genes. This pattern is observed in our analysis of publicly available data, where microarray data or EST data are used to detect male-biased genes in D. melanogaster and to measure their expression levels. This is consistent with the idea that limitations in transcription rates may prevent male-biased genes from accumulating on the X chromosome.
Keywords: Drosophila melanogaster; Dosage compensation; X chromosome; Genomic distribution; Sex-biased genes
Journal Title: Journal of Molecular Evolution
Volume: 68
Issue 5
ISSN: 0022-2844
Publisher: Springer  
Date Published: 2009-05-01
Start Page: 576
End Page: 583
Sponsor: This work was funded by a Portuguese Foundation for Science and Technology scholarship to B.V., and B.C. was supported by the Royal Society
DOI: 10.1007/s00239-009-9235-4
Open access: no