Fast-spiking parvalbumin^+ GABAergic interneurons: From cellular design to microcircuit function Journal Article


Author(s): Hu, Hua; Gan, Jian; Jonas, Peter
Article Title: Fast-spiking parvalbumin^+ GABAergic interneurons: From cellular design to microcircuit function
Affiliation IST Austria
Abstract: The success story of fast-spiking, parvalbumin-positive (PV+) GABAergic interneurons (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy. In 1995, the properties of these interneurons were completely unknown. Twenty years later, thanks to the massive use of subcellular patch-clamp techniques, simultaneous multiple-cell recording, optogenetics, in vivo measurements, and computational approaches, our knowledge about PV+ interneurons became more extensive than for several types of pyramidal neurons. These findings have implications beyond the “small world” of basic research on GABAergic cells. For example, the results provide a first proof of principle that neuroscientists might be able to close the gaps between the molecular, cellular, network, and behavioral levels, representing one of the main challenges at the present time. Furthermore, the results may form the basis for PV+ interneurons as therapeutic targets for brain disease in the future. However, much needs to be learned about the basic function of these interneurons before clinical neuroscientists will be able to use PV+ interneurons for therapeutic purposes.
Keywords: parvalbumin; 4 aminobutyric acid receptor
Journal Title: Science
Volume: 345
Issue 6196
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2014-08-01
Start Page: Article number: 1255263
URL:
DOI: 10.1126/science.1255263
Notes: Acknowledgments: We thank J. Csicsvari, T. Freund, S. Hippenmeyer, T. Klausberger, J. Lisman, and I. Soltesz for critically reading the manuscript; A. Solymosi for text editing; and all colleagues at IST Austria for generating a stimulating scientific environment. This work was supported by the Fond zur Förderung der Wissenschaftlichen Forschung (grant P 24909-B24 to P.J.) and the European Union (European Research Council Advanced Grant 268548 to P.J.). We apologize for the fact that, owing to space constraints, not all relevant papers could be cited.
Open access: yes (repository)