TTP: Tool for tumor progression Journal Article


Author(s): Reiter, Johannes G; Božić, Ivana; Chatterjee, Krishnendu; Nowak, Martin A
Article Title: TTP: Tool for tumor progression
Title Series: LNCS, CAV'13
Affiliation IST Austria
Abstract: In this work we present a flexible tool for tumor progression, which simulates the evolutionary dynamics of cancer. Tumor progression implements a multi-type branching process where the key parameters are the fitness landscape, the mutation rate, and the average time of cell division. The fitness of a cancer cell depends on the mutations it has accumulated. The input to our tool could be any fitness landscape, mutation rate, and cell division time, and the tool produces the growth dynamics and all relevant statistics.
Keywords: Cancer; tumor progression; somatic evolution
Journal Title: Proceedings of 25th Int. Conf. on Computer Aided Verification
Volume: 8044
ISSN: 978-3-642-39799-8
Publisher: Springer  
Date Published: 2013-01-01
Start Page: 101
End Page: 106
URL:
DOI: 10.1007/978-3-642-39799-8_6
Notes: This work is supported by the ERC Start grant (279307: Graph Games), the FWF NFN Grant (No S11407-N23, Rise), the FWF Grant (No P 23499-N23), a Microsoft Faculty Fellow Award, the Foundational Ques- tions in Evolutionary Biology initiative of the John Templeton Foundation, and the NSF/NIH joint program in mathematical biology (NIH grant R01GM078986).
Open access: yes (repository)