A three-plane architectonic atlas of the rat hippocampal region Journal Article


Author(s): Boccara, Charlotte N; Kjønigsen, Lisa J; Hammer, Ingvild M; Bjaalie, Jan Gunnar; Leergaard, Trygve B; Witter, Menno P
Article Title: A three-plane architectonic atlas of the rat hippocampal region
Affiliation IST Austria
Abstract: The hippocampal region, comprising the hippocampal formation and the parahippocampal region, has been one of the most intensively studied parts of the brain for decades. Better understanding of its functional diversity and complexity has led to an increased demand for specificity in experimental procedures and manipulations. In view of the complex 3D structure of the hippocampal region, precisely positioned experimental approaches require a fine-grained architectural description that is available and readable to experimentalists lacking detailed anatomical experience. In this paper, we provide the first cyto- and chemoarchitectural description of the hippocampal formation and parahippocampal region in the rat at high resolution and in the three standard sectional planes: coronal, horizontal and sagittal. The atlas uses a series of adjacent sections stained for neurons and for a number of chemical marker substances, particularly parvalbumin and calbindin. All the borders defined in one plane have been cross-checked against their counterparts in the other two planes. The entire dataset will be made available as a web-based interactive application through the Rodent Brain WorkBench (http://www.rbwb.org) which, together with this paper, provides a unique atlas resource.
Keywords: Hippocampus; 3D atlas; Chemoarchitecture; Cytoarchitecture; Parahippocampal region
Journal Title: Hippocampus
Volume: 25
Issue 7
ISSN: 1098-1063
Publisher: Wiley-Blackwell  
Date Published: 2015-07-01
Start Page: 838
End Page: 857
Sponsor: Funded by Kavli Foundation; The Research Council of Norway (Centre of Excellence and equipment grants, MPW); The EC Human Brain Project (JGB); The Norwegian Node of the International Neuroinformatics Coordinating Facility (INCF)
URL:
DOI: 10.1002/hipo.22407
Notes: We thank Bruno Monterotti, Ellen Husby, Dmitri Darine, and Gergely Csúcs for expert technical assistance and Martyna Chekinska for help with the figures.
Open access: no