Excitement about inhibitory presynaptic terminals Journal Article


Author(s): Vandael, David H; Espinoza, Claudia; Jonas, Peter
Article Title: Excitement about inhibitory presynaptic terminals
Alternate Title: Neuron
Affiliation IST Austria
Abstract: Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (2015) show that at Purkinje cell-deep cerebellar nuclei neuron synapses, changes in presynaptic action potential waveform substantially contribute to synaptic depression. Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (2015) show that at Purkinje cell-deep cerebellar nuclei neuron synapses, changes in presynaptic action potential waveform substantially contribute to synaptic depression.
Keywords: Synaptic Transmission; priority journal; short survey; potassium channel; interneuron; voltage gated sodium channel; Purkinje cell; GABAergic system; calcium channel; neurotransmitter release; calcium transport; synapse vesicle; cerebellum nucleus; inhibitory postsynaptic potential; nerve ending; nerve potential; patch clamp technique; synaptic depression
Journal Title: Neuron
Volume: 85
Issue 6
ISSN: 0896-6273
Publisher: Elsevier  
Date Published: 2015-03-18
Start Page: 1149
End Page: 1151
URL:
DOI: 10.1016/j.neuron.2015.03.006
Open access: yes (repository)