Adaptive response and enlargement of dynamic range Journal Article


Author(s): Friedlander, Tamar; Brenner, Naama
Article Title: Adaptive response and enlargement of dynamic range
Affiliation
Abstract: Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. Adaptive response is thought to be related to various cellular functions such as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modeling framework. We show that any particular type of adaptive response is neither sufficient nor necessary for adaptive enlargement of dynamic range. In particular a precise adaptive response, where system activity is maintained at a constant level at steady state, does not ensure a large dynamic range neither in input signal nor in system output. A general mechanism for input dynamic range enlargement can come about from the activity-dependent modulation of protein responsiveness by multiple biochemical modification, regardless of the type of adaptive response it induces. Therefore hierarchical biochemical processes such as methylation and phosphorylation are natural candidates to induce this property in signaling systems.
Keywords: Feedback; biological networks; Adaptive response; Dynamic range; Integral control; Signal processing
Journal Title: Mathematical Biosciences and Engineering
Volume: 8
Issue 2
ISSN: 1551-0018
Publisher: Arizona State University  
Date Published: 2011-04-02
Start Page: 515
End Page: 526
URL:
DOI: 10.3934/mbe.2011.8.515
Open access: yes (repository)