Dynamics of Dpp signaling and proliferation control Journal Article


Author(s): Wartlick, Ortrud; Mumcu, Peer; Kicheva, Anna; Bittig, Thomas; Seum, Carole; Jülicher, Frank; González-Gaitán, Marcos A
Article Title: Dynamics of Dpp signaling and proliferation control
Affiliation
Abstract: Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded concentration profiles that control patterning and growth of developing organs. In the imaginal discs, proliferative growth is homogeneous in space, posing the conundrum of how morphogen concentration gradients could control position-independent growth. To understand the mechanism of proliferation control by the Dpp gradient, we quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development. On average, cells divide when Dpp signaling levels have increased by 50%. Our observations are consistent with a growth control mechanism based on temporal changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism generates position-independent growth rates.
Keywords: Cell Proliferation; Signal Transduction; Drosophila Proteins; morphogenesis; growth rate; Drosophila melanogaster; cytology; molecular analysis; decapentaplegic protein; concentration response; forelimb; Intercellular Signaling Peptides and Proteins
Journal Title: Science
Volume: 331
Issue 6021
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2011-03-04
Start Page: 1154
End Page: 1159
DOI: 10.1126/science.1200037
Notes: P.M., T.B., and F.J. were supported by the Max-Planck-Gesellschaft. O.W., A.K., C.S., and M.G.-G. were supported by Geneva University and by European Research Council advanced investigator grant (SARA), SystemsX (LipidX), Swiss National Science Foundation (SNF), National Centre of Competence in Research (NCCR) chemical biology and Frontiers in Genetics and R'equip grants
Open access: no