Temporal dynamics of patterning by morphogen gradients Journal Article


Author(s): Kutějová, Eva; Briscoe, James; Kicheva, Anna
Article Title: Temporal dynamics of patterning by morphogen gradients
Affiliation
Abstract: Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.
Keywords: Models, Biological; Time Factors; Cell Differentiation; Signal Transduction; Gene Expression Regulation; morphogenesis; Body Patterning; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; gene interaction
Journal Title: Current Opinion in Genetics & Development
Volume: 19
Issue 4
ISSN: 0959-437X
Publisher: Elsevier  
Date Published: 2009-08-01
Start Page: 315
End Page: 322
Sponsor: EK is supported by an EMBO LTF, AK by a FEBS fellowship, and JB by MRC (UK) and the Wellcome Trust
DOI: 10.1016/j.gde.2009.05.004
Open access: no