Dynamics of anisotropic tissue growth Journal Article


Author(s): Bittig, Thomas; Wartlick, Ortrud; Kicheva, Anna; González-Gaitárr, Marcos; Julicher, Frank
Article Title: Dynamics of anisotropic tissue growth
Affiliation
Abstract: We study the mechanics of tissue growth via cell division and cell death (apoptosis). The rearrangements of cells can on large scales and times be captured by a continuum theory which describes the tissue as an effective viscous material with active stresses generated by cell division. We study the effects of anisotropies of cell division on cell rearrangements and show that average cellular trajectories exhibit anisotropic scaling behaviors. If cell division and apoptosis balance, there is no net growth, but for anisotropic cell division the tissue undergoes spontaneous shear deformations. Our description is relevant for the study of developing tissues such as the imaginal disks of the fruit fly Drosophila melanogaster, which grow anisotropically.
Keywords: Cell Proliferation; Cells; cell death; Apoptosis; anisotropy; Continuum mechanics; Crystallography; Active stressing; Balance (weighting); Cell divisions; Continuum theory; Drosophila melanogaster (DmTrxR); Fruit flies; Scaling behaviors; Tissue growth
Journal Title: New Journal of Physics
Volume: 10
ISSN: 1367-2630
Publisher: IOP Publishing Ltd.  
Date Published: 2008-06-03
Start Page: Article number: 063001
DOI: 10.1088/1367-2630/10/6/063001
Open access: yes (OA journal)