A giant molecular proton pump: structure and mechanism of respiratory complex I Journal Article


Author(s): Sazanov, Leonid
Article Title: A giant molecular proton pump: structure and mechanism of respiratory complex I
Affiliation IST Austria
Abstract: The mitochondrial respiratory chain, also known as the electron transport chain (ETC), is crucial to life, and energy production in the form of ATP is the main mitochondrial function. Three proton-translocating enzymes of the ETC, namely complexes I, III and IV, generate proton motive force, which in turn drives ATP synthase (complex V). The atomic structures and basic mechanisms of most respiratory complexes have previously been established, with the exception of complex I, the largest complex in the ETC. Recently, the crystal structure of the entire complex I was solved using a bacterial enzyme. The structure provided novel insights into the core architecture of the complex, the electron transfer and proton translocation pathways, as well as the mechanism that couples these two processes.
Keywords: bacterial protein; proton pump; bacterial enzyme; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); cytochrome c oxidase; ubiquinol cytochrome c reductase
Journal Title: Nature Reviews Molecular Cell Biology
Volume: 16
Issue 6
ISSN: 1471-0080
Publisher: Nature Publishing Group  
Date Published: 2015-05-22
Start Page: 375
End Page: 388
DOI: 10.1038/nrm3997
Notes: The work in the author's laboratory in the Medical Research Council Mitochondrial Biology Unit (Cambridge, UK) was funded by the UK Medical Research Council. Additional funding was provided by the Royal Society and the European Molecular Biology Organization (EMBO).
Open access: no
IST Austria Authors
  1. Leonid A. Sazanov
    47 Sazanov