Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells Journal Article


Author(s): Strüber, Michael; Jonas, Peter; Bartos, Marlene
Article Title: Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells
Affiliation IST Austria
Abstract: GABAergic perisoma-inhibiting fast-spiking interneurons (PIIs) effectively control the activity of large neuron populations by their wide axonal arborizations. It is generally assumed that the output of one PII to its target cells is strong and rapid. Here, we show that, unexpectedly, both strength and time course of PII-mediated perisomatic inhibition change with distance between synaptically connected partners in the rodent hippocampus. Synaptic signals become weaker due to lower contact numbers and decay more slowly with distance, very likely resulting from changes in GABAA receptor subunit composition. When distance-dependent synaptic inhibition is introduced to a rhythmically active neuronal network model, randomly driven principal cell assemblies are strongly synchronized by the PIIs, leading to higher precision in principal cell spike times than in a network with uniform synaptic inhibition.
Keywords: Synaptic Transmission; Interneurons; dentate gyrus; gamma oscillations; basket cell
Journal Title: PNAS
Volume: 112
Issue 4
ISSN: 1091-6490
Publisher: National Academy of Sciences  
Date Published: 2015-01-27
Start Page: 1220
End Page: 1225
URL:
DOI: 10.1073/pnas.1412996112
Notes: This work was supported by grants of the Lichtenberg Award (Volkswagenstiftung) (to M.B.), the Schram Foundation (to M.B.), Brain-Links Brain-Tools, Cluster of Excellence funded by the Deutsche Forschungsgemeinschaft EXC 1086 (to M.B.), the German Research Foundation [DFG BA 1582/2-1 and FOR2143 (to M.B.); the Excellence Initiative, GSC-4, Spemann Graduate School (to M.S.)], the Scottish Universities Life Sciences Alliance (to M.S.), the Fond zur Förderung der Wissenschaftlichen Forschung (P 24909-B24) (to P.J.), and the European Union (European Research Council Advanced Grant 268548) (to P.J.).
Open access: yes (repository)