Activity dependent plasticity of hippocampal place maps Journal Article


Author(s): Schönenberger, Philipp; O'Neill, Joseph; Csicsvári, József
Article Title: Activity dependent plasticity of hippocampal place maps
Affiliation IST Austria
Abstract: Hippocampal neurons encode a cognitive map of space. These maps are thought to be updated during learning and in response to changes in the environment through activity-dependent synaptic plasticity. Here we examine how changes in activity influence spatial coding in rats using halorhodopsin-mediated, spatially selective optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression in many place cells and interneurons; some place cells increase their firing through disinhibition, whereas some show no effect. We find that place fields of the unaffected subpopulation remain stable. On the other hand, place fields of suppressed place cells were unstable, showing remapping across sessions before and after optogenetic inhibition. Disinhibited place cells had stable maps but sustained an elevated firing rate. These findings suggest that place representation in the hippocampus is constantly governed by activity-dependent processes, and that disinhibition may provide a mechanism for rate remapping.
Keywords: Hippocampus; Synaptic plasticity; Rattus
Journal Title: Nature Communications
Volume: 7
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2016-06-10
Start Page: Article number: 11824
Copyright Statement: CC-BY
URL:
DOI: 10.1038/ncomms11824
Notes: We thank Susanne Laukoter (IST Austria) for help with immunohistochemsitry and Robert Hauschild for help with the optogenetics setup; Peter Jonas and Charlotte Boccara for comments on an earlier version of the manuscript; K. Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP plasmid through Addgene. This work was supported by European Research Council Consolidator Grant (281511), Austrian Science Fund (FWF01_I2072) and a Swiss National Science Foundation grant to P.S.
Open access: yes (OA journal)