Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses Journal Article


Author(s): Vyleta, Nicholas P; Borges-Merjane, Carolina; Jonas, Peter
Article Title: Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
Affiliation IST Austria
Abstract: Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network.
Journal Title: eLife
ISSN: 2050-084X
Publisher: eLife Sciences Publications  
Date Published: 2016-10-25
Start Page: Article number: 7788479: 5:e17977
Copyright Statement: CC BY 4.0
URL:
DOI: 10.7554/eLife.17977
Notes: This project has received funding from the Austrian Science Fund (FWF P 24909-B24) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme with grant agreement numbers 268548 and 692692 (to PJ). We thank Drs. Jozsef Csicsvari, Jose Guzmán, John Lisman, and Alessandro Treves for critically reading the manuscript. We also thank F Marr for technical assistance, E Kramberger for manuscript editing, as well as T Asenov (Miba machine shop) and M Schunn (preclinical facility) for efficient help. #MaschineShop #PreclinicalFacility
Open access: yes (OA journal)