Immune priming in arthropods: an update focusing on the red flour beetle Review Article

Author(s): Milutinović, Barbara; Peuß, Robert; Ferro, Kevin; Kurtz, Joachim
Title: Immune priming in arthropods: an update focusing on the red flour beetle
Affiliation IST Austria
Abstract: Immune priming has now been demonstrated in a wide range of invertebrate species. Studies testing this phenomenon largely differ in terms of experimental design, host–parasite combinations, agents used for priming, and in particular the degree of demonstrated specificity of the primed response. This review provides an overview of known and putative mechanisms underlying broad-spectrum and specific immune priming in arthropods. We focus on insects and particularly the red flour beetle Tribolium castaneum, where priming has been demonstrated within and across generations. We will also draw attention to the relevance of routes of priming and infection, which can occur septically and orally, with largely differing physiology. For oral priming, an involvement of gut microbiota was demonstrated in mosquitoes and flour beetles. Generally, a primed state could result from long-lasting immune activation or a form of memory that does not entail lingering immune components. Moreover, the primed state could also be of a qualitatively different kind than the challenge response. Finally, we will consider that there should be natural variation in priming capability, and therefore a possibility to study this trait with experimental evolution approaches.
Keywords: immune priming; Tribolium castaneum; Immune specificity; Infection route
Publication Title: Zoology
Volume: 119
Issue 4
ISBN: 1873-2720
Publisher: Elsevier  
Date Published: 2016-08-01
Start Page: 254
End Page: 261
Copyright Statement: CC BY-NC-ND 4.0
DOI: 10.1016/j.zool.2016.03.006
Notes: The authors thank Sophie A.O. Armitage and Jan N. Offenborn for helpful comments on the figures, and two anonymous reviewers for their helpful comments. The project was funded by the Deutsche Forschungsgemeinschaft (DFG, KU 1929/4-2) within the priority programme SPP 1399 “Host–Parasite Coevolution”.
Open access: yes (OA journal)